Trailblazing actress, star of ‘The Mary Tyler Moore Show,’ earned six Emmys and an Oscar nomination.

Mary Tyler Moore, the Emmy-winning sitcom star and Oscar-nominated actress best known for her role in The Mary Tyler Moore Show and the 1980 movie Ordinary People, died on Wednesday in Connecticut. Moore’s publicist, Mara Buxbaum, confirmed the star’s death to the Associated Press. “Today, beloved icon Mary Tyler Moore passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine,” Buxbaum said in a statement. The cause of death was cardiopulmonary arrest due to pneumonia, according to The New York Times.

“Mary Tyler Moore was a once-in-a-generation talent,” CBS chairman and CEO Leslie Moonves said in a statement. “She will be long remembered as a gifted actress, television pioneer and a role model to so many. CBS has lost one of the very best to ever grace our airwaves and our industry has lost a true legend and friend.”
“Mary Tyler Moore’s humor, style and vulnerability have had a profound influence on me as a television creator and on every woman I know working in television to upend expectations of traditional femininity,” added Lena Dunham. “Her remarkable presence and ahead-of-her-time ability to expose the condition of single working womanhood with humor and pathos will never be forgotten. Her generosity as an animal rights activist and icon will never be forgotten. I never met her and I’ll love her forever. I know I’m one of millions.”

Moore’s most recent film appearance was in Against the Current in 2009. She also made cameos on the show Hot in Cleveland in 2011 and 2013, reuniting with her old Mary Tyler Moore Show cast members Betty White and Georgia Engel. Moore is survived by her third husband, Dr. Robert Levine. They married in 1983.